Synthesis of an unnatural N-glycan-linked dolichyl pyrophosphate precursor.
نویسندگان
چکیده
An unnatural alpha-D-mannopyranose-linked chitobiosyl dolichyl pyrophosphate, a stereoisomer of the N-glycan biosynthesis intermediate, was synthesized. The protected trisaccharide, alpha-D-Man-(1-->4)-beta-D-GlcNAc-(1-->4)-D-GlcNAc, carrying a 4-methylbenzoyl group was prepared for the convenience of a TLC analysis. 1-O-Phosphorylation, condensation with dolichyl phosphate, and subsequent deprotection afforded the title compound.
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ورودعنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 67 8 شماره
صفحات -
تاریخ انتشار 2003